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Images in Clinical Radiology

Intravascular Leiomyosarcoma in the Left Renal Vein


Jae Young Lee,

Department of Radiology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan-si, KR
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Seung Soo Kim

Department of Radiology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan-si, KR
About Seung Soo
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Main teaching point: The typical imaging feature of intravascular leiomyosarcoma is a heterogeneous enhancing mass within an expanded vessel.
How to Cite: Lee JY, Kim SS. Intravascular Leiomyosarcoma in the Left Renal Vein. Journal of the Belgian Society of Radiology. 2019;103(1):56. DOI:
  Published on 04 Oct 2019
 Accepted on 22 Sep 2019            Submitted on 19 Aug 2019

Case History

A 52-year-old woman presented with a two-month history of intermittent left flank pain. Her past medical history was unremarkable except for hysterectomy for uterine leiomyoma. Results of urinalysis and tumor markers were within the normal ranges as follows: 1–4 leukocytes and <1 erythrocytes per high-power field; carbohydrate antigen (CA 19–9), 4.52 U/ml; and carcinoembryonic antigen (CEA), 0.92 ng/ml. Contrast-enhanced computed tomography (CT) was performed for evaluation of flank pain. An axial and coronal reformatted contrast-enhanced CT image (Figure 1) showed a 7-cm, tubular, heterogeneous, enhancing mass (arrow) with a well-defined margin within the left renal vein. An elongated left ovarian vein (arrowheads) with collateral vessels (open arrowheads) was also detected. Positron emission tomography-CT image (Figure 2) revealed mild fluorodeoxyglucose uptake (max Standardized Uptake Value, 3.0) in the mass (arrow). The patient underwent mass excision and left nephrectomy and was diagnosed with leiomyosarcoma of the left renal vein. On gadoxetic acid-enhanced magnetic resonance imaging performed 19 months later (Figure 3), a recurrent metastatic lesion (open arrow) was detected in the liver, and she underwent right hemihepatectomy.

Figure 1 
Figure 2 
Figure 3 


Leiomyosarcoma is a common primary retroperitoneal sarcoma and is the most common sarcoma that arises from the blood vessels. It is classified by growth pattern into extravascular (62%), intravascular (5%), and both extravascular and intravascular (33%) types. The intravascular type of leiomyosarcomas frequently occurs in the inferior vena cava, and those arising from the renal vein are rare [1].

The CT finding of intravascular leiomyosarcomas reveals a heterogeneous enhancing lesion within an expanded vessel, which is uncommon for a thrombus. The intravascular leiomyosarcomas usually show a well-circumscribed margin with a mean size greater than 10 cm. Calcification is an uncommon feature for leiomyosarcoma. The near-total obstruction of the involved vessel may be accompanied by collateral vessels. Metastases are common in the intravascular type, and common metastatic sites are lung, liver, peritoneum, and pleura. En bloc resection of the tumor includes nephrectomy and is the treatment of choice for intravascular leiomyosarcoma in the renal vein [1].

Ethics and Consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Statement of informed consent was not applicable because the manuscript does not contain any patient data.

Funding Information

This work was supported by the Soonchunhyang University Research Fund and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2018R1C1B5085419).

Competing Interests

The authors have no competing interests to declare.


  1. Marko, J and Wolfman, DJ. Retroperitoneal leiomyosarcoma from the radiologic pathology archives. RadioGraphics. 2018; 38(5): 1403–20. DOI: 

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