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Original Article

Evaluation of peri-tumoral vessels surrounding colorectal liver metastases after intravenous injection of extruded magnetoliposomes in rats: correlation with 3t mri and histopathology

Authors:

K Coenegrachts ,

Department of Radiology, AZ St.-Jan Brugge-Oostende AV, Bruges, Belgium
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J van Werven,

Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
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L ter Beek,

Philips Healthcare, Eindhoven, The Netherlands
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Z Mzallassi,

Department of Surgery/Surgical Laboratory, Academic Medical Center, Amsterdam, The Netherlands
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M Bögels,

Department of Molecular Cell biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
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Th van Gulik,

Department of Surgery/Surgical Laboratory, Academic Medical Center, Amsterdam, The Netherlands
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I Van Den Berghe,

Department of Pathology, AZ St.-Jan Brugge-Oostende AV, Bruges, Belgium
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A Nederveen,

Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
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J Stoker,

Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
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H Rigauts,

Department of Radiology, AZ St.-Jan Brugge-Oostende AV, Bruges, Belgium
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S Soenen,

Interdisciplinary Research Center, Catholic University Leuven-Campus Kortrijk, Kortrijk, Belgium
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M De Cuyper

Interdisciplinary Research Center, Catholic University Leuven-Campus Kortrijk, Kortrijk, Belgium
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Abstract

Background: Magnetoliposomes have pronounced signal-enhancing effect on T1-weighted (T1w) images of the liver using qualitative analysis which may be benefical for demonstrating peritumoral vasculature. Purpose: To correlate peri-tumoral vasculature (ring-enhancement) surrounding colorectal liver metastases after injection of magnetoliposomes using T1-weighted (T1w) imaging with histopathology in a rat model.
Material and Methods: All experiments were approved by the responsible Animal Care Committee. Three rats injected with CC531 coloncarcinoma cells in the portal vein were imaged at 3T using a small diameter four channel coil. The presence of liver metastases, signal intensity changes within intrahepatic vessels, peri-tumoral vasculature (ringenhancement) surrounding liver metastases on T1w imaging and histopathology, and the histopathological distribution of iron particles were evaluated. SS SE-EPI and T1w GE sequences were used. Images were evaluated qualitatively and MRI findings were correlated with histopathology. Results: Fifteen liver metastases were present which were all detected at MRI (mean diameter 2.4 mm (SD 0.8 mm, range 1.5 -4.7 mm)). Ring-enhancement surrounding liver metastases at contrast-enhanced T1w GE sequences was present in all liver metastases. Correlation with histopathology showed the corresponding presence of dilated sinusoids filled with iron particles surrounding the liver metastases.
Conclusion: Blood-pooling of iron oxide particles within magnetoliposomes was demonstrated with increased and hyperintensity of vessels after injection of magnetoliposomes. Qualitatively, ring-enhancement surrounding the liver metastases was seen on T1w imaging and corresponded histopathologically with the presence of iron particles (magnetoliposomes) within the dilated sinusoids surrounding the liver metastases.

How to Cite: Coenegrachts K, van Werven J, ter Beek L, Mzallassi Z, Bögels M, van Gulik T, et al.. Evaluation of peri-tumoral vessels surrounding colorectal liver metastases after intravenous injection of extruded magnetoliposomes in rats: correlation with 3t mri and histopathology. Journal of the Belgian Society of Radiology. 2005;93(2):87–91. DOI: http://doi.org/10.5334/jbr-btr.147
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Published on 07 Feb 2005.
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