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Original Article

Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI

Authors:

R Dautry ,

Service de Radiologie, Hôpital Bichat - Claude Bernard, Paris, France, FR
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V J Bousson,

Service de Radiologie Ostéo-articulaire, Hôpital Lariboisière, Université Paris Diderot Paris - 7
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J Manelfe,

Service de Radiologie, Hôpital Bichat - Claude Bernard, Paris, France, Université Paris Diderot Paris - 7
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A Perozziello,

Unité de Recherche Clinique Hôpital Bichat - Claude Bernard
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P Boyer,

Service de Chirurgie Orthopédique Hôpital Bichat - Claude Bernard
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Ph Loriaut,

Service de Chirurgie Orthopédique Hôpital Bichat - Claude Bernard
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P Koch,

Service de Radiologie, Hôpital Bichat - Claude Bernard, Paris, France, FR
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A Silvestre,

Centre d’Imagerie Ostéo-articulaire, Clinique du Sport, Bordeaux-Mérignac, France, FR
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E Schouman-Claeys,

Service de Radiologie, Hôpital Bichat - Claude Bernard, Paris, France, Université Paris Diderot Paris - 7
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J D Laredo,

Service de Radiologie Ostéo-articulaire, Hôpital Lariboisière, Université Paris Diderot Paris - 7
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B Dallaudière

Service de Radiologie, Hôpital Bichat - Claude Bernard, Paris, France, Université Paris Diderot Paris - 7, Hôpital Bichat - Claude Bernard, Inserm U698, Paris, France
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Abstract

Objective: To assess the correlation of T2 mapping abnormalities to knee pain location, in young adults with normal standard knee MRI at 3.0 Tesla.

Subjects and methods: Twenty-three consecutive patients were included prospectively from September 2011 to April 2012. Inclusion criteria were age under 50 years old, knee pain without surgical history, and normal knee MRI at 3.0 Tesla (sagittal T1-weighted images, and sagittal, axial and coronal proton-density-weighted images with saturation of fat signal). Ten asymptomatic volunteers were also included as a control group. Patients and controls had a cartilage T2 mapping MRI sequence in addition to the standard MRI protocol. Two musculoskeletal radiologists, blinded to the patient/control condition and pain location, independently reviewed the T2 mapping images. T2 values below 40 ms were considered normal. They rated the number of hyaline cartilage lesions and their grade according to an ICRS-like score (inspired by the International Cartilage Research Society score) in each anatomical compartment (medial and lateral femoro-tibial and anterior patello-femoral joints). In addition, the T2 value of the largest lesion was measured. Patient’s pain location was classified in the following categories: anterior, lateral, medial and global. T2 mapping findings were compared to pain location, and retrospectively to the initial standard sequences. Sensitivity and specificity were calculated for MRI with T2 mapping according to pain location for each reader. Kappa coefficient was calculated for inter-reader agreement. We used variance analysis in a linear regression to compare T2 values and ICRS-like classification in each compartment.

Results: Sensitivity of MRI with T2 mapping, according to the symptomatic compartment, was respectively: 78% and 87% for Reader 1 and Reader 2 and specificity was 70% for both readers. Kappa coefficient for T2 mapping abnormalities location and pain location was good, with a calculated value of 0.64. There was no significant correlation between ICRS-like classification and T2 values of lesions (p = 0.18).

Conclusion: Our results suggest that T2 mapping is an interesting MRI sequence for the exploration of young patients knee pain in case of normal MRI with a standard protocol, with a good correlation between pain location and focal prolongations of the cartilage T2 relaxation time.

How to Cite: Dautry, R. et al., (2014). Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI. Journal of the Belgian Society of Radiology. 97(1), pp.11–16. DOI: http://doi.org/10.5334/jbr-btr.364
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Published on 01 Jan 2014.
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