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Pulmonary Langerhans histiocytosis and eosinophilic granuloma.

Authors:

M Demeter ,

Department of Radiology, Imelda Hospital, Bonheiden, Belgium
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Y Vankan,

Department of Radiology, Imelda Hospital, Bonheiden, Belgium
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F De Somer,

Department of Radiology, Imelda Hospital, Bonheiden, Belgium
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D Perdieus

Department of Radiology, Imelda Hospital, Bonheiden, Belgium
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Abstract

A forty-tree-year-old female patient presented at the emergency department for low back pain and left hip pain since four weeks, mostly at night, and disabled walking. Neurological examination and laboratory findings were normal. Computed tomography of the lumbar spine showed degenerative discopathy at level L4-L5 and L5-S1, but revealed no other lesions explaining the patient’s acute complaints. Additional plain radiograph of the left hip revealed an oval cyst-like lucent lesion in the left iliopubic ramus with thinning of the adjacent cortical margin (Fig. A). A magnetic resonance imaging (MRI) for further exploration was proposed. The MRI revealed a T1 hypointense lesion surrounded by increased signal intensity on T2 images, consistent to an osteolytic lesion with peri-lesional bone marrow edema, and a concomitant fracture of the iliopubic ramus. SPECTCT confirmed the presence of a lytic bone lesion in the left iliopubic ramus with high tracer intensity (Fig. B), as well as three smaller osteolytic lesions in both ileum bones without tracer uptake. Considering the possibility of bone metastasis, thoracic and abdominal CT examination was performed to rule out a primary tumor. Both lungs showed multiple small cysts with irregular wall thickness, as well as numerous millimetric pulmonary nodules with groundglass and more dense appearance, both localized in the upper and middle lung zones, with sparing of the lung bases and costophrenic angles (Fig. C). The diagnosis of pulmonary Langerhans cell histiocytosis and eosinophilic granuloma was suggested. An ultrasound-guided percutaneous biopsy of the bone lesion in the left iliopubic ramus was performed. Histological and immunohistochemical examination of the biopt revealed a cluster of eosinophilic granulocyts staining for S100 protein and CD1 antigen, a specific Langerhans cell marker. The diagnosis of ‘pulmonary Langerhans cell histiocytosis’ and ‘eosinophilic granuloma’ was confirmed.

How to Cite: Demeter M, Vankan Y, Somer FD, Perdieus D. Pulmonary Langerhans histiocytosis and eosinophilic granuloma.. Journal of the Belgian Society of Radiology. 2012;95(3):177. DOI: http://doi.org/10.5334/jbr-btr.613
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Published on 01 May 2012.
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