The appearance of cystic Brunner’s gland hamartomas (BGHs) on computed tomography (CT) or magnetic resonance imaging (MRI) has only been reported in a very small number of cases. Imaging diagnosis of cystic BGHs is usually difficult. We present a case of cystic BGH and characterize it in conjunction with previously reported cases. We found that the cysts of BGHs are smaller than those of other cystic duodenal lesions. The presence of cysts in BGHs can limit the differential diagnosis to cystic duodenal lesions, and our observations may assist others in the discrimination of cystic BGHs from other cystic duodenal lesions.