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Original Article

Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case

Authors:

B Coulier ,

Department of Diagnostic Radiology Loverval, Belgium, BE
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F Pierard,

Department of Visceral Surgery, Loverval, Belgium, BE
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I Gielen,

Institute of Pathology and Genetics, Loverval, Belgium, BE
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Ph Maldague

Department of Gastroenterology, Clinique St Luc, Bouge (Namur)
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Abstract

We report the CT, surgical and histopathologic findings of a rare case of Hepatic Angiosarcoma (HAS) diagnosed in a 85-year old women 65 years after Thorotrast (Th²³²) exposure for angiography. At the early arterial phase of dynamic MDCT, peripheral curvilinear and central nodular puddling of contrast produced in the 8 cm tumor. Then progressive contrast filling of the tumor was observed on the delayed scans. Associated pathognomonic signs related to previous Th²³² exposure were also found comprising diffuse intrahepatic reticular bands of calcifications, numerous calcified epigastric lymph nodes and a calcified shrunken spleen. Emergency laparotomy was performed because of associated hemoperitoneum. With a delay of 65 years after Thorotrast exposure, this historical case probably represents, to our knowledge, the most delayed presentation of Th²³² related HAS ever published.

How to Cite: Coulier B, Pierard F, Gielen I, Maldague P. Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case. Journal of the Belgian Society of Radiology. 2014;97(4):254–8. DOI: http://doi.org/10.5334/jbr-btr.85
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Published on 01 May 2014.
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